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overview Research in Dr. McCarrey’s lab is centered on mammalian germ cells and stem cells. Experimental models include the mouse, the baboon, and the opossum. The lab is interested in the epigenetic regulation of cell functions, including determination of cell fates, maintenance of genetic integrity, regulation of gene expression, genomic imprinting, X-chromosome inactivation and meiotic sex chromosome inactivation, methods of assisted reproduction, the evolution of tissue-specific gene expression in mammalian species, and developing the baboon as a model system for testing stem cell-based therapeutic applications.
One or more keywords matched the following items that are connected to McCarrey, John R.
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Academic Article Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development.
Academic Article A set of genes critical to development is epigenetically poised in mouse germ cells from fetal stages through completion of meiosis.
Academic Article Derivation of induced pluripotent stem cells from the baboon: a nonhuman primate model for preclinical testing of stem cell therapies.
Academic Article Co-regulation of pluripotency and genetic integrity at the genomic level.
Academic Article TSPAN8 Expression Distinguishes Spermatogonial Stem Cells in the Prepubertal Mouse Testis.
Academic Article Pluripotent cells display enhanced resistance to mutagenesis.
Academic Article Differentiation and Characterization of Dopaminergic Neurons From Baboon Induced Pluripotent Stem Cells.
Academic Article Advantages of nonhuman primates as preclinical models for evaluating stem cell-based therapies for Parkinson's disease.
Academic Article Dynamic Variations in Genetic Integrity Accompany Changes in Cell Fate.
Academic Article Optimization of culture conditions for the derivation and propagation of baboon (Papio anubis) induced pluripotent stem cells.
Academic Article The Mammalian Spermatogenesis Single-Cell Transcriptome, from Spermatogonial Stem Cells to Spermatids.
Academic Article Differentiation: the selective potentiation of chromatin domains.
Academic Article Changes in DNA loop domain structure during spermatogenesis and embryogenesis in the Syrian golden hamster.
Academic Article Primate spermatogonial stem cells colonize mouse testes.
Concept Stem Cells
Concept Stem Cell Transplantation
Concept Totipotent Stem Cells
Concept Pluripotent Stem Cells
Concept Embryonic Stem Cells
Concept Induced Pluripotent Stem Cells
Academic Article Unique Epigenetic Programming Distinguishes Regenerative Spermatogonial Stem Cells in the Developing Mouse Testis.
Academic Article OGG1 protects mouse spermatogonial stem cells from reactive oxygen species in culture?.
Academic Article An mTORC1-dependent switch orchestrates the transition between mouse spermatogonial stem cells and clones of progenitor spermatogonia.
Academic Article Differential RA responsiveness among subsets of mouse late progenitor spermatogonia.
Academic Article Germ cells: ENCODE's forgotten cell type?.
Academic Article Validation of baboon pluripotent cells as a model for translational stem cell research.
Academic Article Efficient generation of marmoset primordial germ cell-like cells using induced pluripotent stem cells.
Academic Article Epigenetic priming as a mechanism of predetermination of spermatogonial stem cell fate.
Academic Article Profiling the Epigenetic Landscape of the Spermatogonial Stem Cell: Part 2-Computational Analysis of Epigenomics Data.
Academic Article Profiling the Epigenetic Landscape of the Spermatogonial Stem Cell-Part 1: Epigenomics Assays.
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